This is not really much of a problem, as it's only really applicable for chaos realm, and very rarely at that.
As the titles says, the game chugs down and freezes for half a second (or more with more damage) after dealing ~5k+ dmg, lasting maybe 30 seconds at the highest damage I dared attempt (109k). Not sure how the calculations are made, but could probably be resolved by adding a flat cap on damage multipliers or some logic to prevent unnecessary calculations with big numbers.
Oh, and thank you for this amazing gem of a game! I'm almost glad there's no time played stat, or I'd probably get embarrassed over the countless hours I've put into circadian dice <3
EDIT: For the curious, Final score of 298331 before I died to a combination of having to give up too much max health and frog poisons :)